1μg (R: reducing condition).
HMGB1/HMG1 His Tag Protein, Mouse
HMGB1/HMG1 His Tag Protein, Mouse
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | High mobility group protein 1 (HMG-1); Hmgb1; Hmg-1; Hmg1; HMG3, SBP-1 |
| Accession | P63158 |
| Amino Acid Sequence | Met1-Glu215 with His tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 30-35kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & ＞90% by SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Ulloa L, et al. (2006) High-mobility group box 1 (HMGB1) protein: friend and foe. Cytokine Growth Factor Rev. 17 (3): 189-201. |
Background
High-mobility group protein B1 (HMGB1), also referred to as high-mobility group protein 1 (HMG-1) or amphoterin, is a member of the HMGB family, which includes HMGB1, HMGB2, and HMGB3. HMGB1 is a non-histone architectural chromosomal protein found in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. It plays a role in the mechanisms of inflammation and damage by binding to TLR4, thereby mediating HMGB1-dependent activation of macrophage cytokine release. This places HMGB1 at the crossroads of sterile and infectious inflammatory responses. Studies have explored HMGB1 as an adjuvant for DNA vaccines and as a potential target for cancer therapy.
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SDS-PAGE
SEC-HPLC
The purity of HMGB1/HMG1 His Tag Protein, Mouse is more than 90% determined by SEC-HPLC.
