Lane M: Marker Lane 1: 2 μg, reduced |
GLP1R full length Flag&His Tag Protein,Human
GLP1R full length Flag&His Tag Protein,Human
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$692 USD
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Product Details
Product Details
Product Specification
| Species | Human | |
| Synonyms | GLP-1; GLP-1-R; GLP-1R | |
| Accession | P43220 | |
| Concentration | 1.08 mg/ml | |
| Amino Acid Sequence | R24-F257, E262-K437, S193C, I196F, S225A, M233C, S271A, I317C, G318I, G361C, K346A, C347F, E387D |
|
| Expression System | Baculovirus-InsectCells | |
| Molecular Weight | 57.3KDa | |
| Endotoxin | <1EU/μg | |
| Conjugation | Unconjugated | |
| Tag | His Tag, Flag Tag | |
| Physical Appearance | Liquid | |
| Storage Buffer | 20 mM HEPES pH 7.5, 150 mM NaCl, 0.05% (w/v) GDN, 0.005% (w/v) CHS. | |
| Stability & Storage |
|
Background
A 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Guidelines
For complete recovery, mix well and spin before use.
Product must not be store in diluted solutions.
Aliquots below 10l are not advisable.
Avoid repetitive freeze-thaw cycles!
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SDS-PAGE
SEC-HPLC
