FITC Mouse Anti-Human CD27 Antibody (S-568-1)
FITC Mouse Anti-Human CD27 Antibody (S-568-1)
Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD27 |
| Synonyms | CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, TNFRSF7 |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | P26842 |
| Clone Number | S-568-1 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 0.2mg/ml |
| Conjugation | FITC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5 μl per million cells in 100μl volume |
Background
CD27 is a transmembrane glycoprotein belonging to the tumor necrosis factor receptor (TNFR) superfamily. It is primarily expressed on activated T cells and natural killer (NK) cells, with lower expression levels found on B cells, monocytes, and dendritic cells. CD27 plays a significant role in regulating immune responses. Specifically, CD27 interacts with its ligand, CD70 (also known as TNFSF7 or tumor necrosis factor ligand superfamily member 7), participating in intercellular signaling. This interaction is crucial for the proliferation, survival, and differentiation of T cells and NK cells. Furthermore, the CD27-CD70 interaction is also involved in the activation, proliferation, and antibody production of B cells.
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