The purity of CXADR/CAR His Tag Protein, Mouse is more than 95% determined by SEC-HPLC.
CXADR/CAR His Tag Protein, Mouse
CXADR/CAR His Tag Protein, Mouse
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Product Details
Product Details
Product Specification
| Species | Mouse |
| Synonyms | Coxsackievirus and adenovirus receptor homolog, CAR, Cxadr, CVB3 BP |
| Accession | NP_001020363.1 |
| Amino Acid Sequence | Ala2-Gly237 with His Tag at C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 32-34kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Philipson, L. et al., 2004, Curr. Top. Microbiol. Immunol. 273:87-111. |
Background
CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I transmembrane glycoprotein that belongs to the CTX family within the immunoglobulin (Ig) superfamily. It is crucial for normal cardiac development in mice. CXADR is proposed to function as a homophilic cell adhesion molecule and is a component of the epithelial apical junction complex, which is essential for maintaining tight junction integrity. It is also likely involved in the transepithelial migration of polymorphonuclear leukocytes (PMNs).
The mature mouse CXADR structure consists of a 218 amino acid (aa) extracellular domain (ECD), which includes a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment, and a 17 aa intracellular domain. Notably, D1 is believed to be responsible for homodimer formation within tight junctions. The ECD of mouse CXADR shares 97% sequence identity with the corresponding regions of human CXADR and 9% sequence identity with those of rat CXADR.
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SEC-HPLC
