• CLECSF6/DCIR/CLEC4A His Tag Protein, Human
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CLECSF6/DCIR/CLEC4A His Tag Protein, Human

CLECSF6/DCIR/CLEC4A His Tag Protein, Human

Catalog Number: UA010704 Reactivity: Human Conjugation: Unconjugated Brand: UA BIOSCIENCE
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Product Details

Product Specification


Species Human
Synonyms CD367 Protein, Human; CLEC4A Protein, Human; CLECSF6 Protein, Human; DCIR Protein, Human; DDB27 Protein, Human; HDCGC13P Protein, Human; LLIR Protein, Human
Accession Q9UMR7
Amino Acid Sequence

Gln70-Leu237, with N-terminal 8*His hhhhhhhhgggsQKYSQLLEKKTTKELVHTTLECVKKNMPVEETAWSCCPKNWKSFSSNCYFISTESASWQDSEKDCARMEAHLLVINTQEEQDFIFQNLQEESAYFVGLSDPEGQRHWQWVDQTPYNESSTFWHPREPSDPNERCVVLNFRKSPKRWGWNDVNCLGPQRSVCEMMKIHL
Expression System HEK293
Molecular Weight 23-28kDa (Reducing)
Purity ＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4.
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Gene ID: 50856, updated on 7-Sep-2023

Background

DCIR, also known as Lectin-like Immunoreceptor (LLIR), is a type II membrane protein belonging to the C-type lectin domain family and is designated CLEC4A. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. DCIR expressed on antigen presenting cells and granulocytes and acts as an inhibitory receptor via an intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM). It may also be involved via its ITIM motif in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.

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SDS-PAGE

1μg (R: reducing condition, N: non-reducing condition).