0.5μg (R: reducing condition, N: non-reducing condition).
Claudin-6 membrane Protein with Flag&His Tag in Detergent, Human
Claudin-6 membrane Protein with Flag&His Tag in Detergent, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Claudin-6; Skullin; CLDN6; Claudin6; Skullin 2 |
| Accession | P56747 |
| Concentration | 0.11 mg/ml by Nanodrop |
| Amino Acid Sequence | Wild type full length with Flag tag at N-Terminal，and His tag at C-Terminal |
| Expression System | HEK293 |
| Molecular Weight | 25.6 kDa |
| Purity | ＞85% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tags & Cleavage sites | N/A |
| Tag | His Tag, Flag Tag |
| Physical Appearance | Liquid |
| Storage Buffer | 50 mM Tris, pH 7.5, 150 mM NaCl, 0.05% DDM |
| Stability & Storage | ·6 months from date of receipt, -60 to -80 °C as supplied. |
| Reference | 1. Du H, Yang X, Fan J and Du X: Claudin 6: Therapeutic prospects for tumours, and mechanisms of expression and regulation (Review). Mol Med Rep 24: 677, 2021. |
Background
Tight junctions (TJs) are essential components of cell connectivity, maintaining cell polarity, permeability, and adhesion, and participating in the regulation of cell proliferation and differentiation. The claudin (CLDN) family is integral to TJs, with Claudin 6 (CLDN6) being a key member. CLDN6 is a transmembrane protein found in tight junctions, featuring two extracellular loops and intracellular N- and C-terminal tails. CLDN6 modulates ion- and charge-specific permeability in the paracellular pathway of most epithelial tissues.CLDN6 is widely expressed in various tumors, including liver, ovarian, endometrial, and esophageal cancers, as well as atypical teratoid/rhabdoid tumors. Given its expression profile, CLDN6 has potential as a carcinoembryonic antigen and a therapeutic target.
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SDS-PAGE
ELISA
Immobilized Human Claudin-6 Antibody at 2.0μg/mL (100μL/well) can bind Claudin6 membrane Protein with Flag and His tag in detergent, Human (Cat. No. UA060005) with EC50 of 7.7-15.7ng/mL.
