2μg (R: reducing conditions, N: non-reducing conditions).
Biotinylated PD-L2 Avi&His Tag Protein, Human
Biotinylated PD-L2 Avi&His Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Antigen | PD-L2 |
| Synonyms | PDL2, PD-L2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2 |
| Accession | Q9BQ51 |
| Amino Acid Sequence | Leu20-Pro219, with C-terminal Avi&8*His tag LFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPGGGSGLNDIFEAQKIEWHEHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 33-43kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Biotin |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Masatsugu Kojima , Satoshi Murata, Eiji Mekata, Katsushi Takebayashi, Elizabeth M Jaffee, Tohru Tani Fusion protein of mutant B7-DC and Fc enhances the antitumor immune effect of GM-CSF-secreting whole-cell vaccine. J Immunother (2014). 37(3):147-54. |
Background
B7-DC [also known as programmed death ligand 2 (PD-L2)] is a costimulatory molecule expressed predominantly on dendritic cells (DCs) and macrophages. In addition to its coinhibitory receptor, programmed death receptor 1 (PD-1), evidence suggests that B7-DC interacts with an unidentified costimulatory receptor on T cells. B7-DC mutants with selective binding capacity for the costimulatory receptor may be effective in stimulating antitumor immune responses, while avoiding the inhibitory effects of PD-1.
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SDS-PAGE
ELISA
Immobilized Biotinylated PD-L2 Avi&His Tag Protein, Human (Cat. No. UA010568) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind PD-1 Fc Chimera Protein, Human (Cat. No. UA010002) with EC50 of 12.38-18.46ng/ml.
