Flow cytometric analysis of human CD42b expression on fresh human peripheral blood platelets. Fresh Human peripheral blood platelets were stained with FITC Mouse Anti-Human CD61 Antibody and either APC Mouse IgG1, k Isotype Control (left panel) or SDT APC Mouse Anti-Human CD42b Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
APC Mouse Anti-Human CD42b Antibody (HIP1)
APC Mouse Anti-Human CD42b Antibody (HIP1)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD42b |
| Synonyms | Platelet glycoprotein Ib alpha chain; GP-Ib alpha; GPIb-alpha; GPIbA; Glycoprotein Ibalpha; Antigen CD42b-alpha; GP1BA |
| Location | Membrane |
| Accession | P07359 |
| Clone Number | HIP1 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Isotype Control | S0B80038 |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Fresh human peripheral blood platelets |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD42b, also known as glycoprotein Ib alpha (GPIbα), is a type I transmembrane glycoprotein expressed on platelets and megakaryocytes. It is a key component of the GPIb-IX-V receptor complex, which plays a critical role in platelet adhesion and thrombus formation by binding to von Willebrand factor (vWF) at sites of vascular injury. CD42b interacts with various molecules, including thrombin, coagulation factors XI and XII, and P-selectin, contributing to hemostasis and thrombosis. Mutations or polymorphisms in CD42b are associated with diseases such as Bernard-Soulier syndrome and platelet-type von Willebrand disease.
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