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Anti-Human IL-1β Monoclonal Antibody (Gevokizumab)

Anti-Human IL-1β Monoclonal Antibody (Gevokizumab)

Catalog Number: S0E0041 Application: Blocking of IL-1β signaling Functional assays Reactivity: Hu Conjugation: Unconjugated Brand: Starter
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$300 USD
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Product Details

Product Specification


Host Human
Antigen IL-1β
Synonyms Interleukin-1 beta; IL-1 beta; Catabolin; IL1F2; IL1B; IL-1 beta
Location Cytoplasm, Secreted, Lysosome
Accession P01584
Clone Number S-4642
Antibody Type Recombinant mAb
Isotype IgG2a,k
Application Blocking of IL-1β signaling Functional assays
Reactivity Hu
Purification Protein A
Concentration 5 mg/ml
Endotoxin <1EU/mg
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, containing no preservative
Stability & Storage

2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.

Background

Interleukin-1 beta (IL-1β) is a pro-inflammatory cytokine that plays a crucial role in the immune response. It is produced by various cell types, including macrophages and monocytes, in response to infections or tissue injury. IL-1β helps to initiate and amplify the inflammatory response by promoting the expression of other inflammatory mediators and recruiting immune cells to the site of infection or damage. It also has effects on a wide range of physiological processes, such as fever induction, modulation of the hypothalamic-pituitary-adrenal axis, and regulation of metabolism. Dysregulation of IL-1β has been implicated in numerous chronic inflammatory diseases, like rheumatoid arthritis and inflammatory bowel disease, making it an important target for therapeutic interventions.

Picture

Western Blot

WB result of Anti-Human IL-1β Monoclonal Antibody (Gevokizumab)
Primary antibody: Anti-Human IL-1β Monoclonal Antibody (Gevokizumab) at 1/1000 dilution
Lane 1: IL-1β Protein, Human 1 µg
Secondary antibody: Goat Anti- human IgG, (H+L), HRP conjugated at 1/10000 dilution
Predicted MW: 31 kDa
Observed MW: 18 kDa

ELISA

Immobilized IL-1β Protein, Human(UA040151) can bind Gevokizumab. The EC50 for this effect is 4.000 ng/mL.