Flow cytometric analysis of Mouse CD41 expression on BALB/c mouse platelets. BALB/c mouse platelets were stained with Alexa Fluor® 647 Rat IgG1, κ Isotype Control (Black line histogram) or SDT Alexa Fluor® 647 Rat Anti-Mouse CD41 Antibody (Red line histogram) at 1.25μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 647 Rat Anti-Mouse CD41 Antibody (MWReg30)
Alexa Fluor® 647 Rat Anti-Mouse CD41 Antibody (MWReg30)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Synonyms | Integrin alpha-IIb; GPalpha IIb (GPIIb); Platelet membrane glycoprotein IIb; Itga2b |
| Location | Membrane |
| Accession | Q9QUM0 |
| Clone Number | MWReg30 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Ms |
Background
CD41, also known as integrin αIIb or platelet glycoprotein IIb, is a crucial protein involved in platelet aggregation and hemostasis. It is encoded by the ITGA2B gene and forms a heterodimer with integrin β3 (CD61) to create the fibrinogen receptor on platelets. This receptor is essential for platelet aggregation, as it binds soluble fibrinogen and other ligands like plasminogen, prothrombin, thrombospondin, vitronectin, and von Willebrand factor. Mutations in the CD41 gene can lead to Glanzmann thrombasthenia, a bleeding disorder characterized by prolonged bleeding after injury. CD41 is also used as a marker to identify platelets, megakaryocytes, and hematopoietic progenitor cells.
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