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NT-proBNP, Human

NT-proBNP, Human

Catalog Number: S0A9019 Brand: Starter
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$370 USD
$370 USD
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Product Details

Product Specification


Species Human
Synonyms NT-proBNP;BNF, BNP, brain type natriuretic peptide, Gamma-brain natriuretic peptide, natriuretic peptide B, natriuretic peptide precursor B, natriuretic peptides B, natriuretic protein, NPPB
Accession P16860
Amino Acid Sequence HHHHHHHPLG SPGSASDLET SGLQEQRNHL QGKLSELQVE QTSLEPLQES PRPTGVWKSR EVATEGIRGH RKMVLYTLRA PR
Expression System E.coli
Molecular Weight 9.2 kDa
Purity ＞95%, by SDS-PAGE under reducing conditions
Endotoxin <0.2EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized powder
Storage Buffer PBS (pH7.2)
Reconstitution Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .
Stability & Storage

· 12 months from date of receipt, -20 to -70 °C as supplied. 
· 6 months, -20 to -70 °C under sterile conditions after reconstitution.
· 1 week, 2 to 8 °C under sterile conditions after reconstitution.  
· Please avoid repeated freeze-thaw cycles.

Background

N-terminal-prohormone Brain Natriuretic Peptide (NT‑proBNP) has a molecular weight of 8.5 kDa and belongs to the natriuretic peptide family. Also known as B‑type natriuretic peptide, it exerts natriuretic, diuretic, and vasodilatory effects. NT‑proBNP is primarily synthesized and secreted by ventricular cardiomyocytes; cardiac dysfunction characterized by excessive ventricular loading and increased wall tension represents the main stimuli for its secretion, with the intensity of these stimuli directly proportional to NT‑proBNP levels. Consequently, NT‑proBNP can specifically and sensitively reflect changes in ventricular function, making it a clinically important biomarker for heart failure that plays an irreplaceable role in early screening and prognosis assessment. This product consists of human-derived NT‑proBNP protein recombinantly expressed in Escherichia coli BL21(DE3), with an N‑terminal His‑tag composed of six histidine residues. After multistep purification, the solution is filtered for sterilization, aliquoted, and lyophilized.

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SDS-PAGE

NT-proBNP，Human ,1μg on SDS-PAGE under Non-reducing and reducing condition. The purity is greater than 95%.