M-CSF Protein, Human (GMP)
M-CSF Protein, Human (GMP)
Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Macrophage colony-stimulating factor 1,M-CSF,CSF-1,Lanimostim |
| Accession | P09603-3 |
| Amino Acid Sequence | Glu33-Ser190 |
| Expression System | CHO |
| Endotoxin | ＜10 EU/mg |
| Host cell protein | ＜500ppm |
| Host cell DNA | ＜100ppb |
| Mycoplasma | Negative |
| Sterility | Conform to |
| phValue | 7.2~7.6 |
| ProteinContent | 90%~120% |
| SdsPageMolecularWeight | 16–23 kDa (reduced) & 30–40 kDa (non-reduced) |
| SdsPagePurity | >97% (non-reducing) |
| SecHplcPurity | >97% |
| CellActivity | < 5ng/ml |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH 7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Single-cell RNA profiling reveals classification and characteristics of mononuclear phagocytes in colorectal cancer Tiantian Ji; Haoyu Fu; Liping Wang; Jinyun Chen; Shaobo Tian; Guobin Wang; Lin Wang; Zheng Wang；PLOS Genetics. 2024 Feb 26 ; 1553-7404 |
Background
Macrophage colony-stimulating factor (M-CSF) is a hematopoietic growth factor that regulates the proliferation, differentiation, and functional activation of monocytes. Normally detected in human serum, M-CSF plays an important role in enhancing the effector functions of mature monocytes and macrophages. M-CSF serum levels are increased in CB and further increased in the neonate. The role of M-CSF is not only restricted to the monocyte/macrophage cell lineage. By interacting with its membrane receptor (CSF1R or M-CSF-R encoded by the c-fms proto-oncogene), M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy. Full length human M-CSF transcripts encode a 522 amino acid (aa) type I transmembrane (TM) protein with a 464 aa extracellular region, a 21 aa TM domain, and a 37 aa cytoplasmic tail.
