Activin A Protein, Human/Mouse/Rat (High Active)

Catalog Number: UA040569 Brand: UA BIOSCIENCE

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$170 USD

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Product Details

Product Specification

Species	Human, Mouse, Rat
Synonyms	Inhibin beta A chain; Activin beta-A chain; Erythroid differentiation protein (EDF);
Accession	P08476
Amino Acid Sequence	Gly311-Ser426, F368A
Expression System	CHO
Molecular Weight	12-14 kDa (Reducing)
Purity	>95% by SDS-PAGE,>90% by HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Physical Appearance	Lyophilized Powder
Storage Buffer	4mM HCl
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in reconstitution buffer (4mM HCl) after rapid centrifugation.
Stability & Storage	·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. ·3 months, -20 to -80℃ under sterile conditions after reconstitution. ·1 week, 2 to 8℃ under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Reference	Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16239-44. Nature. 2000 Mar 23;404(6776):411-4. Dev Cell. 2005 Oct;9(4):535-43.

Background

Activin A is a dimeric glycoprotein belonging to the transforming growth factor-beta (TGF-β) superfamily of cytokines. It is involved in various biological processes, including embryonic development, reproductive function, and regulation of the immune system. Activin A is produced by a wide range of cell types, including immune cells, endothelial cells, and reproductive tissues. It exerts its effects by binding to the activin type II receptors, leading to the activation of downstream signaling pathways involved in cell proliferation, differentiation, and immune modulation. Activin A has been implicated in the regulation of inflammation, tissue repair, and the pathogenesis of various diseases, including cancer and autoimmune disorders.

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Bioactivity

Measured by its ability to induce activin-responsive firefly luciferase reporter activity in HepG2 cells. The EC50 for this effect is typically 0.59-1.2 ng/ml.