Human Erbb2, His Tag

Catalog Number: S0A0012 Brand: Starter

Price:

$300 USD

Size: 50μg 100μg

Quantity:

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Product Details

Product Specification

Species	Human
Synonyms	Metastatic lymph node gene 19 protein (MLN19)、Proto-oncogene Neu、Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2
Amino Acid Sequence	QVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTGGGGSHHHHHHHHHH
Expression System	HEK293
Molecular Weight	95kDa
Purity	＞95% by SDS-PAGE
Endotoxin	Please contact us for more information.
Conjugation	Unconjugated
Tag	with C-His Tag
Physical Appearance	Lyophilized powder
Storage Buffer	Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 with 3% trehalose.
Reconstitution	Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage	12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

Background

Erbb2 is a member of the human epidermal growth factor receptor family. Amplification or over-expression of Erbb2 has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. It is strongly associated with increased disease recurrence and a poor prognosis. Over-expression of Erbb2 is also known to occur in ovarian, stomach, adenocarcinoma of the lung and aggressive forms of uterine cancer. Due to its critical role in cancer development and progression, Erbb2 is the target of the monoclonal antibody trastuzumab.

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Bioactivity

Immobilized Human Erbb2, His Tag at 1 μg/mL (100 μL/well) can bind Anti-HER2 Monoclonal Antibody (Pertuzumab) (Cat. No. S0B0568) with EC50 of 0.37-0.64 ng/mL.

Immobilized Human Erbb2, His Tag at 1 μg/mL (100 μL/well) can bind Anti-Human HER2 Monoclonal Antibody (Trastuzumab) (Cat. No. S0B0572) with EC50 of 0.40-0.61 ng/mL.