Human CD47, hFc tag

Catalog Number: S0A1052 Brand: Starter

Price:

$45 USD

Size: 10μg 25μg 50μg 100μg 500μg

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Product Details

Product Specification

Species	Human
Synonyms	Antigenic surface determinant protein OA3, Integrin-associated protein (IAP), Protein MER6, MER6
Accession	Q08722
Expression System	HEK293
Molecular Weight	Theoretical:40kDa Actual:65kDa
Purity	＞95% by SDS-PAGE
Endotoxin	<1EU/mg
Tag	with C-hFc Tag
Physical Appearance	Lyophilized powder
Storage Buffer	Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, 1mM EDTA, pH7.4 with 3% trehalose.
Reconstitution	Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage	12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

Background

CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 (TSP-1) and signal-regulatory protein alpha (SIRPα). CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis. CD47 is involved in a range of cellular processes, including apoptosis, proliferation, adhesion, and migration. Furthermore, it plays a key role in immune and angiogenic responses. CD47 is ubiquitously expressed in human cells and has been found to be overexpressed in many different tumor cells. Expression in equine cutaneous tumors has been reported as well.