IHC shows positive staining in paraffin-embedded mouse cerebral cortex. Anti- Phospho-α-Synuclein (Ser129) antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
Phospho-α-Synuclein (Ser129) Recombinant Rabbit mAb (SDT-3397)
Phospho-α-Synuclein (Ser129) Recombinant Rabbit mAb (SDT-3397)
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Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | Phospho-α-Synuclein (Ser129) |
| Synonyms | Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor (NACP); NACP; PARK1; SNCA |
| Location | Cytoplasm, Nucleus, Secreted, Synapse |
| Accession | P37840 |
| Clone Number | SDT-3397 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
| IHC-P | 1:250 | Ms, Rt |
Background
Phospho-α-Synuclein (Ser129) is the pathognomonic form of α-synuclein in which the serine at position 129 is stoichiometrically phosphorylated, a post-translational switch that converts the natively unfolded presynaptic protein into a sticky, aggregation-prone seed capable of nucleating Lewy bodies and Lewy neurites, propagating trans-synaptically between neurons, activating microglia and complement, and serving as the most specific biochemical correlate of dopaminergic neurodegeneration in Parkinson’s disease and dementia with Lewy bodies.
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Immunohistochemistry
IHC shows positive staining in paraffin-embedded old mouse cerebral cortex. Anti- Phospho-α-Synuclein (Ser129) antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded rat cerebral cortex. Anti- Phospho-α-Synuclein (Ser129) antibody was used at 1/250 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
