InvivoPro anti-mouse PD-1 Recombinant mAb (D265A)
InvivoPro anti-mouse PD-1 Recombinant mAb (D265A)
Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | PD-1 |
| Synonyms | Programmed cell death protein 1, mPD-1, CD279 |
| Location | Cell membrane |
| Accession | Q02242 |
| Clone Number | RMP1-14 |
| Antibody Type | Recombinant mAb |
| Isotype | Mouse IgG1 D265A, κ |
| Isotype Control | S0B0788 |
| Mutations | D265A |
| Application | in vivo blocking of PD-1/PD-L signaling |
| Reactivity | Ms |
| Purification | Protein G |
| Concentration | 10 mg/ml |
| Purity | >95% (Determined by SEC-HPLC) |
| Pathogen Tests |
Ectromelia Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus (MAD1, MAD2): Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mycoplasma Pulmonis: Negative Mouse Rotavirus: Negative Minute Virus of Mice: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis Virus: Negative |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Background
Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein on the surface of T and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).
