Flow cytometric analysis of Mouse CD117 expression on BALB/c mouse bone marrow. BALB/c mouse bone marrow was stained with FITC Rat Anti-Mouse CD34 Antibody and either PE-Cy7 Rat IgG2b, κ Isotype Control (Left panel) or SDT PE-Cy7 Rat Anti-Mouse CD117 Antibody (Right panel) at 1.25 μl/test treated with True-Stain Monocyte Blocker™. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
PE-Cy7 Rat Anti-Mouse CD117 Antibody (S-R681)
PE-Cy7 Rat Anti-Mouse CD117 Antibody (S-R681)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD117 |
| Synonyms | Mast/stem cell growth factor receptor Kit; SCFR; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; Sl; Kit; c-Kit |
| Location | Cytoplasm, Cell membrane |
| Accession | P05532 |
| Clone Number | S-R681 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse bone marrow |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | PE-Cy7 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Ms |
Background
c-Kit (CD117) is a receptor tyrosine kinase encoded by the c-kit gene. It plays a crucial role in the development and function of various cell types including hematopoietic cells, melanocytes, and gastrointestinal interstitial cells. The ligand for c-Kit is stem cell factor (SCF), and the binding of SCF to c-Kit activates intracellular signaling pathways that promote cell proliferation, survival, differentiation, and migration. Mutations or overexpression of c-Kit are associated with several diseases such as gastrointestinal stromal tumors (GISTs) and certain types of leukemia, making it an important target for therapeutic interventions.
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