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Mouse Anti-Human LAT1/CD98 complex Antibody (S-3441)

Mouse Anti-Human LAT1/CD98 complex Antibody (S-3441)

Catalog Number: S0B8268 Application: FCM Reactivity: Human Conjugation: Unconjugated Brand: Starter
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$131.00 SGD
$131.00 SGD
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Product Details

Product Specification


Host Mouse
Antigen LAT1/CD98 complex
Synonyms Large neutral amino acids transporter small subunit 1; 4F2 light chain (4F2 LC; 4F2LC); CD98 light chain; Integral membrane protein E16 (E16); L-type amino acid transporter 1 (hLAT1); Solute carrier family 7 member 5; y+ system cationic amino acid transporter; CD98LC; LAT1 s; MPE16; SLC7A5
Location Lysosome, Cell membrane
Accession Q01650
Clone Number S-3441
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample A549
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:50 Hu

Background

The LAT1/CD98 complex is a heterodimeric, sodium-independent amino acid transporter composed of the catalytic light chain LAT1 (SLC7A5) and the heavy chain CD98 (4F2hc/SLC3A2), which acts as a chaperone to stabilize LAT1 and escort it to the plasma membrane where it exchanges large neutral amino acids such as leucine, phenylalanine and tryptophan to fuel mTORC1 signaling and support growth, particularly in tumors that overexpress the complex.

Picture

FC

Flow cytometric analysis of LNCAP (Human prostate carcinoma epithelial cell, Left) / A549 (Human lung carcinoma epithelial cell, Right) labelling LAT1/CD98 antibody at 1/50 dilution (4 μg) / (Red) compared with a Mosue IgG1, κ (Black) Isotype Control. Goat Anti - Mouse IgG Alexa Fluor® 647 was used as the secondary antibody.
Negative control:LNCAP