Flow cytometric analysis of 4% PFA fixed 0.1% Tween-20 permeabilized IFN-γ treated PBMC (Human peripheral blood mononuclear cells) labelling CXCL10 antibody at 1/200 dilution (1 μg)/ (Right panel) compared with a Mouse IgG2a, κ Isotype Control (Left panel). Goat Anti - Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD14 - Brilliant Violet 421™ antibody separately.
Mouse Anti-Human CXCL10 Antibody (S-2970)
Mouse Anti-Human CXCL10 Antibody (S-2970)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CXCL10 |
| Synonyms | C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein (Gamma-IP10; IP-10); Small-inducible cytokine B10; INP10; SCYB10 |
| Location | Secreted |
| Accession | P02778 |
| Clone Number | S-2970 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | ICFCM |
| Reactivity | Hu |
| Positive Sample | IFN-γ treated PBMC |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 1:200 | Hu |
Background
CXCL10, also known as interferon γ-induced protein 10 kDa (IP-10), is a cytokine belonging to the CXC chemokine family. It exerts its biological effects by binding to the CXCR3 receptor and plays a crucial role in immune responses. CXCL10 is a pleiotropic molecule with diverse functions, including promoting the chemotaxis of CXCR3+ cells, inducing apoptosis, regulating cell growth and proliferation, and modulating angiogenesis in infectious diseases, inflammation, and cancer. It is primarily produced by various cell types in response to IFN-γ and is involved in activating T lymphocytes, NK cells, macrophages, dendritic cells, and B cells. Elevated levels of CXCL10 are associated with several pathological conditions, such as autoimmune diseases, viral infections, and tumor development.
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