Flow cytometric analysis of Human Peripheral Blood labelling Human CD244 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Mouse IgG2a, κ Isotype Control / (left panel). Goat Anti-Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD56 - PE antibody separately.
Mouse Anti-Human CD244 Antibody (S-2854)
Mouse Anti-Human CD244 Antibody (S-2854)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD244 |
| Synonyms | Natural killer cell receptor 2B4; NK cell activation-inducing ligand (NAIL); NK cell type I receptor protein 2B4 (NKR2B4; h2B4); SLAM family member 4 (SLAMF4); Signaling lymphocytic activation molecule 4; 2B4 |
| Location | Cell membrane |
| Accession | Q9BZW8 |
| Clone Number | S-2854 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human Peripheral Blood |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD244, also known as 2B4 or SLAMF4, is a type-I transmembrane protein belonging to the signaling lymphocytic activation molecule (SLAM) family. It is expressed on various immune cells, including NK cells, T cells, monocytes, eosinophils, myeloid-derived suppressor cells, and dendritic cells. CD244 primarily binds to CD48, another member of the SLAM family, to regulate immune responses through both stimulatory and inhibitory signals. Its cytoplasmic domain contains four immunoreceptor tyrosine-based switch motifs (ITSMs) that interact with proteins like SAP, EAT2, and phosphatases to transmit signals. CD244 plays a significant role in immune regulation and has potential as a therapeutic target in diseases such as cancer and autoimmune disorders.
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