Flow cytometric analysis of Human Peripheral Blood cells labelling Human CD141 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Mouse IgG1, κ Isotype Control / (left panel). Goat Anti-Mouse IgG Alexa Fluor® 647 was used as the secondary antibody.
Mouse Anti-Human CD141 Antibody (S-2870)
Mouse Anti-Human CD141 Antibody (S-2870)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD141 |
| Synonyms | Thrombomodulin; TM; Fetomodulin; THRM; THBD |
| Location | Membrane |
| Accession | P07204 |
| Clone Number | S-2870 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human Peripheral Blood cells |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD141, also known as thrombomodulin, is a 75 kDa single-chain type I membrane glycoprotein that serves as a crucial cofactor in the protein C anticoagulant system. It is expressed on various cell types, including endothelial cells, monocytes, dendritic cells, and keratinocytes. When thrombin binds to CD141, it activates protein C, which degrades clotting factors Va and VIIIa, thereby reducing thrombin generation and preventing excessive blood coagulation. Additionally, CD141 is involved in embryonic development and atherosclerotic plaque formation. In the immune system, CD141+ dendritic cells have been shown to produce significant amounts of IFN-α in response to certain stimuli, indicating their important role in immune responses.
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