Flow cytometric analysis of Human PBMC (human peripheral blood mononuclear cells) labelling Human CD126 antibody at 1/200 (1 μg) dilution/ (Right panel) compared with a Mouse IgG1, κ Isotype Control / (left panel). Goat Anti-Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD19 - Brilliant Violet 421™ antibody separately.
Mouse Anti-Human CD126 Antibody (S-2911)
Mouse Anti-Human CD126 Antibody (S-2911)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD126 |
| Synonyms | Interleukin-6 receptor subunit alpha; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80 (gp80); IL6R |
| Location | Cell membrane |
| Accession | P08887 |
| Clone Number | S-2911 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD126, also known as the interleukin-6 receptor alpha chain (IL-6Rα), is a type I cytokine receptor that plays a crucial role in regulating cell growth and differentiation in various tissues. It is a subunit of the IL-6 receptor complex, which also includes the signal-transducing subunit glycoprotein 130 (gp130 or CD130). CD126 is primarily expressed on B cells, epithelial cells, and hepatocytes. The binding of IL-6 to CD126 forms a complex that, in association with CD130, initiates signaling pathways involved in immune responses and acute phase reactions. Dysregulated production of IL-6 and CD126 is implicated in the pathogenesis of several diseases, including multiple myeloma, autoimmune diseases, and certain cancers. Additionally, CD126 is being explored as a potential therapeutic target for CAR-T cell therapy due to its expression in various tumors.
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