Flow cytometric analysis of Human CD163 expression on Human PBMC. Human PBMC (peripheral blood mononuclear cells) were stained with Brilliant Violet 480™ Mouse Anti-Human CD14 Antibody and either Biotin Mouse IgG1, κ Isotype Control (Left panel) or Biotin Mouse Anti-Human CD163 Antibody (Right panel) at 5 μl/test followed by Sav-PE. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Biotin Mouse Anti-Human CD163 Antibody (S-3028)
Biotin Mouse Anti-Human CD163 Antibody (S-3028)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD163 |
| Synonyms | Scavenger receptor cysteine-rich type 1 protein M130; Hemoglobin scavenger receptor; M130 |
| Location | Secreted, Cell membrane |
| Accession | Q86VB7 |
| Clone Number | S-3028 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD163 is a type I membrane protein primarily expressed on the surface of monocytes and macrophages and belongs to the scavenger receptor cysteine-rich (SRCR) superfamily. It plays a crucial role in regulating immune responses and clearing heme proteins. CD163 binds to haptoglobin-hemoglobin complexes, facilitating iron recycling and protecting tissues from oxidative damage. As a marker of M2-type macrophages, CD163 is associated with anti-inflammatory functions by inhibiting the production of pro-inflammatory cytokines. In pathological conditions, the expression levels of CD163 are linked to various diseases, including inflammatory disorders, cancer, and viral infections. Soluble CD163 (sCD163) is often used as a biomarker for disease monitoring and assessment.
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