Alexa Fluor® 700 Mouse Anti-Human CD11a Antibody (S-R402)

CD11a, also known as integrin alpha L, is a protein encoded by the ITGAL gene in humans and is a critical component of the leukocyte function-associated antigen-1 (LFA-1) complex, which is essential for immune cell adhesion and signaling. It pairs with CD18 to form LFA-1, a heterodimeric transmembrane protein that mediates interactions between leukocytes and other cells, such as T cells and antigen-presenting cells. This interaction is crucial for leukocyte migration to sites of inflammation and the formation of immunological synapses. CD11a is expressed on all leukocytes and plays a key role in immune surveillance and inflammatory responses. It is also a target for therapeutic agents like efalizumab, which was used to treat psoriasis by inhibiting the interaction between LFA-1 and its ligands, such as ICAM-1.