Alexa Fluor® 647 Mouse Anti-Human CD288 Antibody (S-2966)

CD288 (also designated as Toll-like receptor 8, TLR8) is an 83 kDa type 1 transmembrane protein belonging to the TLR family, predominantly expressed in lung and peripheral blood leukocytes, and encoded by the TLR8 gene located on the X chromosome. It functions as an endosomal receptor that recognizes GU-rich single-stranded RNA (ssRNA) and G-rich oligonucleotides from viral pathogens (e.g., influenza, HIV, HCV), leading to recruitment of MyD88 and activation of NF-κB, thereby inducing proinflammatory cytokine synthesis and antiviral responses . Additionally, TLR8 (CD288) is involved in dendritic cell activation and the regulation of tumor growth, making it a target in cancer therapy research (e.g., ovarian cancer, lymphomas).