Flow cytometric analysis of Human CD141 expression on human PBMC (human peripheral blood mononuclear cell). Human PBMC were stained with either Alexa Fluor® 647 Mouse IgG1, κ Isotype Control (Left panel) or SDT Alexa Fluor® 647 Mouse Anti-Human CD141 Antibody (Right panel) at 1.25 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 647 Mouse Anti-Human CD141 Antibody (S-2870)
Alexa Fluor® 647 Mouse Anti-Human CD141 Antibody (S-2870)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD141 |
| Synonyms | Thrombomodulin; TM; Fetomodulin; CD141; THRM; THBD |
| Location | Membrane |
| Accession | P07204 |
| Clone Number | S-2870 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD141, also known as thrombomodulin, is a 75 kDa single-chain type I membrane glycoprotein that serves as a crucial cofactor in the protein C anticoagulant system. It is expressed on various cell types, including endothelial cells, monocytes, dendritic cells, and keratinocytes. When thrombin binds to CD141, it activates protein C, which degrades clotting factors Va and VIIIa, thereby reducing thrombin generation and preventing excessive blood coagulation. Additionally, CD141 is involved in embryonic development and atherosclerotic plaque formation. In the immune system, CD141+ dendritic cells have been shown to produce significant amounts of IFN-α in response to certain stimuli, indicating their important role in immune responses.
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