Alexa Fluor® 647 Mouse Anti-Human CD103 Antibody (S-2876)

CD103, also known as integrin αEβ7, is a transmembrane heterodimer complex primarily expressed on tissue-resident memory T cells (T RM cells), regulatory T cells (Tregs), and certain dendritic cells. It binds to E-cadherin on epithelial cells, mediating lymphocyte adhesion and retention in tissues such as the skin, gut, and lungs. This interaction is crucial for immune surveillance and maintaining tissue integrity. CD103 expression is regulated by TGF-β, which enhances its ability to bind E-cadherin. In cancer research, CD103 is significant in tumor-infiltrating lymphocytes (TILs), influencing immune responses within tumors. Additionally, CD103 plays a role in cytotoxic T cell activation and effective tumor cell lysis.