Alexa Fluor® 488 Rat Anti-Mouse CD200R3 Antibody (Ba13)

CD200R3, also known as CD200 receptor 3 or CMRF-35-like molecule 1 (CLM-1), is an inhibitory immunoreceptor belonging to the immunoglobulin superfamily that is primarily expressed on myeloid cells such as macrophages, dendritic cells, and granulocytes. Structurally characterized by two extracellular immunoglobulin-like domains and a cytoplasmic tail containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs), CD200R3 functions as a critical negative regulator of innate immune responses by binding to its ligand, CD200 (OX-2), which is widely expressed on various cell types including neurons and endothelial cells. Upon ligand engagement, the receptor's ITIMs become phosphorylated, recruiting phosphatases like SHP-1 and SHP-2 to dampen downstream signaling cascades, thereby suppressing pro-inflammatory cytokine production, limiting excessive immune activation, and maintaining tissue homeostasis, particularly in contexts such as neuroinflammation, tumor microenvironments, and the prevention of autoimmunity.