Flow cytometric analysis of Mouse CD186 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with Brilliant Violet 421™ Rat Anti-Mouse CD3 antibody and either Alexa Fluor® 488 Rat IgG2b, κ Isotype Control (Left panel) or SDT Alexa Fluor® 488 Rat Anti-Mouse CD186 Antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 488 Rat Anti-Mouse CD186 antibody (S-R602)
Alexa Fluor® 488 Rat Anti-Mouse CD186 antibody (S-R602)
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Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD186 |
| Synonyms | C-X-C chemokine receptor type 6; CXC-R6; CXCR-6; Cxcr6 |
| Location | Cell membrane |
| Accession | Q9EQ16 |
| Clone Number | S-R602 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD186, also known as CXCR6, is a 39 kD G-protein coupled chemokine receptor with seven transmembrane-spanning regions. It is expressed on various immune cells, including activated and memory T cells, NKT cells, and some plasma cells. Its ligand is CXCL16, which is expressed by macrophages, dendritic cells, and liver endothelial cells. CD186 plays a role in cell migration and recruitment to inflamed sites and is also a coreceptor for HIV and SIV.
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