IL-28A/IFN-λ2 Protein, Human

Catalog Number: UA040337 Brand: UA BIOSCIENCE

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$164 USD

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Product Details

Product Specification

Species	Human
Synonyms	Interferon lambda-2; IFN-lambda-2; Cytokine Zcyto20; Interleukin-28A (IL-28A);
Accession	Q8IZJ0
Amino Acid Sequence	Val26-Val200, with C-terminal 8*His
Expression System	HEK293
Molecular Weight	24 kDa (Reducing)
Purity	>95% by SDS-PAGE and HPLC.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH 7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	J Virol. 2010 Jun;84(11):5670-7. Epub 2010 Mar 24.

Background

Interleukin-28A (IL-28A), also known as interferon lambda-2 (IFN-λ2), is a member of the type III interferon family. It is produced in response to viral infections and plays a critical role in the innate immune response. IL-28A exhibits antiviral activity by inducing the expression of interferon-stimulated genes (ISGs) and activating immune cells to inhibit viral replication and spread. IL-28A is primarily expressed by immune cells, such as dendritic cells and macrophages, and acts through the IFN-λ receptor complex to exert its antiviral effects. Due to its role in antiviral defense and immune regulation, IL-28A has garnered significant interest as a potential therapeutic target for viral infections, including hepatitis C and respiratory viruses.