Measured in a cell proliferation assay using MC/9 mouse mast cells. The ED50 for this effect is 0.6‑0.9 ng/mL.
IL-10 Protein, Canine
IL-10 Protein, Canine
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Product Details
Product Details
Product Specification
| Species | Canine |
| Synonyms | Interleukin-10; IL-10; Cytokine synthesis inhibitory factor (CSIF); |
| Accession | P48411 |
| Amino Acid Sequence | Ser20-ILe181 |
| Expression System | E.coli |
| Molecular Weight | 20 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | J Interferon Cytokine Res. 1995 Dec;15(12):1103-9. |
Background
Interleukin-10 (IL-10) is a key immunoregulatory cytokine that plays a crucial role in modulating immune responses and maintaining immune homeostasis. In dogs, IL-10 is produced by various immune cells, including monocytes, macrophages, and T cells, and functions as an anti-inflammatory cytokine by inhibiting the production of pro-inflammatory mediators and suppressing immune cell activation. IL-10 is involved in regulating immune tolerance, controlling excessive inflammation, and promoting tissue repair in dogs. Studies on canine IL-10 have focused on its role in infectious diseases, autoimmune conditions, and cancer, highlighting its importance in canine health and disease.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
ELISA
Immobilized IL-10 Protein, Canine (Cat. No. UA040332) at 5.0μg/mL (100μL/well) can bind IL10RA/CD210 His Tag Protein, Human (Cat. No. UA010657) with EC50 of 13.83-14.08 ng/mL.
