Measured in a cell proliferation assay using MC/9 mouse mast cells. The ED50 for this effect is 2.0‑3.6 ng/mL.
IL-10 Protein, Bovine
IL-10 Protein, Bovine
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Product Details
Product Details
Product Specification
| Species | Bovine |
| Synonyms | Interleukin-10; IL-10; Cytokine synthesis inhibitory factor (CSIF); |
| Accession | P43480 |
| Amino Acid Sequence | Ser19-Lys178 |
| Expression System | E.coli |
| Molecular Weight | 18 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Gene. 1994 Feb 25;139(2):257-61. |
Background
Interleukin-10 (IL-10) is a cytokine with potent anti-inflammatory and immunosuppressive properties that plays a crucial role in regulating immune responses and maintaining immune homeostasis. IL-10 is produced by various immune cells, including macrophages, T cells, and B cells, and functions by inhibiting the production of pro-inflammatory cytokines and suppressing the antigen-presenting and effector functions of immune cells. IL-10 is involved in modulating immune tolerance, preventing excessive inflammation, and promoting tissue repair. In cattle, IL-10 has been studied for its role in regulating immune responses during infections, inflammatory conditions, and autoimmune diseases. Understanding the functions and regulatory mechanisms of bovine IL-10 can provide insights into the immune system of cattle and potential therapeutic strategies for managing immune-related disorders in livestock.
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Bioactivity
SDS-PAGE
2μg (R: reducing condition, N: non-reducing condition).
ELISA
Immobilized IL-10 Protein, Bovine (Cat. No. UA040331) at 5.0μg/mL (100μL/well) can bind IL10RA/CD210 His Tag Protein, Human (Cat. No. UA010657) with EC50 of 3.13-5.15 ng/mL.
