IFN-β Protein, Mouse

Catalog Number: UA040355 Brand: UA BIOSCIENCE

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$192 USD

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Product Details

Product Specification

Species	Mouse
Synonyms	Interferon beta; IFN-beta; Ifnb1; Ifb; Ifnb;
Accession	P01575
Amino Acid Sequence	Ile22-Asn182, with C-terminal His Tag
Expression System	HEK293
Molecular Weight	30-40 kDa (Reducing)
Purity	>95% by SDS-PAGE and HPLC.
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. ·3 months, -20 to -80℃ under sterile conditions after reconstitution. ·1 week, 2 to 8℃ under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Reference	Nat Rev Immunol. 2014 Jan;14(1):36-49.

Background

Interferon beta (IFN-β) is a type I interferon that plays a critical role in the immune response to viral infections and other pathogens. In mice, IFN-β is produced by various cell types, including fibroblasts, macrophages, and dendritic cells, in response to viral infection or other stimuli. Upon secretion, IFN-β binds to the interferon alpha/beta receptor (IFNAR) on target cells, leading to the activation of signaling pathways that induce the expression of interferon-stimulated genes (ISGs). These ISGs have antiviral, immunomodulatory, and anti-proliferative effects, contributing to the host defense against viral infections and the regulation of immune responses. IFN-β is also used as a therapeutic agent for the treatment of multiple sclerosis due to its immunomodulatory properties.