Flow cytometric analysis of rat CD44 expression on SD Rat splenocytes. SD Rat splenocytes were stained with PE Mouse Anti-Rat CD3 Antibody and either Biotin Mouse IgG2a, k Isotype Control (left panel) or SDT Biotin Mouse Anti-Rat CD44 Antibody (right panel) at 2 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Biotin Mouse Anti-Rat CD44 Antibody (S-R623)
Biotin Mouse Anti-Rat CD44 Antibody (S-R623)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD44 |
| Synonyms | CD44 antigen; Extracellular matrix receptor III (ECMR-III); GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Hermes antigen; Hyaluronate receptor; Cd44 |
| Location | Secreted, Cell membrane |
| Accession | P26051 |
| Clone Number | S-R623 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Rt |
| Positive Sample | SD Rat splenocytes |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μg per million cells in 100μl volume | Rt |
Background
CD44H, also termed CD44s or the “standard/hematopoietic” isoform, is the smallest CD44 splice variant (≈37 kDa core, 80–95 kDa fully glycosylated) that lacks all variably spliced exons and functions as the cell’s dominant hyaluronan receptor, orchestrating hematopoietic progenitor trafficking, T-cell activation, angiogenesis, and tumor metastasis by coupling extracellular matrix adhesion to cytoskeletal signaling through its cytoplasmic tail-ERM-actin linkage and by serving as a membrane scaffold for metalloproteinases and growth-factor presentation.
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