APC Rat Anti-Mouse/Human CD49f Antibody (GoH3)
APC Rat Anti-Mouse/Human CD49f Antibody (GoH3)
Product Details
Product Details
Product Specification
| Host | Rat |
| Antigen | CD49f |
| Synonyms | Integrin alpha-6; CD49 antigen-like family member F; VLA-6; ITGA6 |
| Location | Cell membrane |
| Accession | P23229、Q61739 |
| Clone Number | GoH3 |
| Antibody Type | Rat mAb |
| Application | FCM |
| Reactivity | Hu, Ms |
| Positive Sample | BALB/c mouse splenocytes, Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.09% sodium azide |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1μg per million cells in 100μl volume | Hu, Ms |
Background
CD49f, also known as integrin α6, is a cell surface protein encoded by the ITGA6 gene. It is a type I transmembrane glycoprotein belonging to the α-subfamily of integrins and can form heterodimers with β1 or β4 subunits to function as α6β1 or α6β4 integrins. CD49f is widely expressed in various cell types, including epithelial cells, T cells, monocytes, and platelets, and plays a crucial role in cell adhesion, proliferation, and differentiation. It is also involved in the regulation of cell stemness, particularly in cancer biology, where it marks tumor-initiating cells with high plasticity and immune evasion capabilities. For example, in hepatocellular carcinoma (HCC), CD49f-high tumor cells can recruit neutrophils to create an immunosuppressive microenvironment, contributing to tumor progression and resistance to immune attack.
