IHC shows positive staining in paraffin-embedded human colon. Anti- Von Willebrand Factor antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
Von Willebrand Factor Recombinant Rabbit mAb (S-663-120)
Von Willebrand Factor Recombinant Rabbit mAb (S-663-120)
Price:
Regular price
$100 USD
Regular price
Sale price
$100 USD
Unit price
per
For shipping services or bulk orders, you may request a quotation.
Secure checkout with
View full details
Product Details
Product Details
Product Specification
| Host | Rabbit |
| Antigen | Von Willebrand Factor |
| Synonyms | vWF, F8VWF |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | P04275 |
| Clone Number | S-663-120 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:200 | null |
Background
Von Willebrand Factor (VWF) is a large multimeric plasma glycoprotein primarily produced by endothelial cells and megakaryocytes. It is found in subendothelial matrices, plasma, and platelets. VWF is synthesized in endothelial cells in the form of Weibel-Palade bodies and in platelets, it is stored in the α-granules. VWF promotes the adhesion and aggregation of platelets at sites of vascular injury, which is a crucial step in the hemostatic process. VWF also serves as a molecular chaperone for coagulation factor VIII, transporting it to sites of injury, stabilizing its heterodimeric structure, and protecting it from premature clearance from the plasma. Furthermore, VWF forms molecular bridges between subendothelial collagen matrices and platelet surface receptor complexes GPIb-IX-V, further facilitating platelet adhesion to sites of vascular injury.
Picture
Picture
Immunohistochemistry
IHC shows positive staining in paraffin-embedded human cardiac muscle. Anti- Von Willebrand Factor antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human skeletal muscle. Anti- Von Willebrand Factor antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human hemangioma of liver. Anti- Von Willebrand Factor antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human bladder cancer. Anti- Von Willebrand Factor antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human cervical squamous cell carcinoma. Anti- Von Willebrand Factor antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
IHC shows positive staining in paraffin-embedded human lung carcinoma. Anti- Von Willebrand Factor antibody was used at 1/200 dilution, followed by a HRP Polymer for Mouse & Rabbit IgG (ready to use). Counterstained with hematoxylin. Heat mediated antigen retrieval with Tris/EDTA buffer pH9.0 was performed before commencing with IHC staining protocol.
