Flow cytometric analysis of Human CD195 expression on human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD3 Antibody and either Alexa Fluor® 647 mouse IgG2a, κ Isotype Control (Left panel) or SDT Alexa Fluor® 647 Mouse Anti-Human CD195 Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 647 Mouse Anti-Human CD195 Antibody (S-R663)
Alexa Fluor® 647 Mouse Anti-Human CD195 Antibody (S-R663)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD195 |
| Synonyms | C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; CCR5; CHEMR13; HIV-1 fusion coreceptor; CMKBR5 |
| Location | Cell membrane |
| Accession | P51681 |
| Clone Number | S-R663 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human PBMC |
| Purification | Protein A |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD195, also known as CCR5, is a G protein-coupled receptor that plays a critical role in immune responses and inflammation. It is expressed on immune cells such as T cells, monocytes, and macrophages, and binds chemokines like MIP-1α, MIP-1β, and RANTES to mediate leukocyte migration and recruitment to sites of inflammation. Additionally, CD195 is a co-receptor for HIV-1, facilitating viral entry into host cells, making it a key target in HIV research and treatment. Its involvement in various diseases, including HIV infection, cancer, and autoimmune disorders, highlights its significance in both immunology and clinical medicine.
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