Flow cytometric analysis of Mouse CD196 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with FITC Rat Anti-Mouse CD45R/B220 Antibody and either Alexa Fluor® 647 Armenian hamster IgG Isotype Control (Left panel) or SDT Alexa Fluor® 647 Armenian hamster Anti-Mouse CD196 Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 647 Armenian hamster Anti-Mouse CD196 Antibody (S-R621)
Alexa Fluor® 647 Armenian hamster Anti-Mouse CD196 Antibody (S-R621)
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Product Details
Product Details
Product Specification
| Host | Armenian hamster |
| Antigen | Mouse CD196 |
| Synonyms | C-C chemokine receptor type 6; C-C CKR-6; CC-CKR-6; CCR-6; KY411; Ccr6; Cmkbr6 |
| Location | Cell membrane |
| Accession | O54689 |
| Clone Number | S-R621 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.05mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD196, also known as CCR6, is a seven-transmembrane, G-protein-coupled receptor that belongs to the beta chemokine receptor family. It is predominantly expressed on B lymphocytes, certain subsets of effector and memory T cells, and immature dendritic cells. CCR6 is a receptor for the CC chemokine CCL20 and also binds with lower affinity to beta-defensin 2. This receptor plays a crucial role in mediating the trafficking of immune cells to epithelial sites near the skin and mucosal surfaces during inflammatory and immunological responses.
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