Flow cytometric analysis of Human CD161 expression on human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Alexa Fluor® 647 Mouse Anti-Human CD4 Antibody and either Alexa Fluor® 488 Mouse IgG1, κ Isotype Control (Left panel) or SDT Alexa Fluor® 488 Mouse Anti-Human CD161 Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
Alexa Fluor® 488 Mouse Anti-Human CD161 Antibody (S-R581)
Alexa Fluor® 488 Mouse Anti-Human CD161 Antibody (S-R581)
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Product Details
Product Details
Product Specification
| Host | Mouse |
| Antigen | CD161 |
| Synonyms | Killer cell lectin-like receptor subfamily B member 1; C-type lectin domain family 5 member B; HNKR-P1a (NKR-P1A); Natural killer cell surface protein P1A; CLEC5B; NKRP1A; KLRB1 |
| Location | Membrane |
| Accession | Q12918 |
| Clone Number | S-R581 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD161 is a C-type lectin-like type II transmembrane protein expressed on natural killer (NK) cells and subsets of T cells, where it functions as an inhibitory receptor on NK cells to suppress cytotoxicity and cytokine secretion, while on T cells it acts as a costimulatory receptor that enhances responsiveness to T-cell receptor (TCR) stimulation by interacting with its ligand LLT1 and is associated with improved survival in various cancers due to its role in amplifying TCR signaling and promoting rapid effector functions.
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