1μg (R: reducing condition, N: non-reducing condition).
Adrenomedullin/ADM Fc Chimera Protein, Human
Adrenomedullin/ADM Fc Chimera Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | AM Protein, Human; PAMP Protein, Human |
| Accession | P35318 |
| Amino Acid Sequence | Tyr95-Tyr146, with N-hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 30-38kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Review Pol J Pharmacol . 2004 Jan-Feb;56(1):5-27. |
Background
Adrenomedullin (ADM) is a 52-amino acid peptide homologous to calcitonin gene-related peptide (CGRP), a member of the adrenomedullin family originally isolated from human pheochromocytoma. It plays a key role in the regulation of many physiological processes, especially those of the cardiovascular and lymphatic systems. It also can be detected in lung, ventricle and kidney tissues. ADM is expressed in a variety of tissues in the human body and is fundamentally involved in multitude biological processes. It is believed that adrenomedullin functions through combinations of the calcitonin receptor like receptor and receptor activity-modifying proteins complexes, as well as CGRP receptors.
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