Human PD-L2, His tag

Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is an immune checkpoint receptor ligand which plays a role in negative regulation of the adaptive immune response. PD-L2 is one of two known ligands for Programmed cell death protein 1 (PD-1). Binding to PD-1 can activate pathways inhibiting TCR/BCR-mediated immune cell activation. PD-L2 plays an important role in immune tolerance and autoimmunity. Both PD-L1 and PD-L2 can inhibit T cell proliferation and inflammatory cytokine production. Blocking PD-L2 has been shown to exacerbate experimental autoimmune encephalomyelitis. Others have shown that treatment with PD-L2 Ig led to T helper cell proliferation. PD-L2, PD-L1, and PD-1 expressions are important in the immune response to certain cancers. Indirectly, PD-L2 may have utility as a biomarker or prognostic indicator.