1μg (R: reducing conditions, N: non-reducing conditions).
CD221/IGF1R His Tag Protein, Human
CD221/IGF1R His Tag Protein, Human
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Insulin-like growth factor I receptor (IGF-I receptor) |
| Accession | P08069 |
| Amino Acid Sequence | Glu31-Asn932, with C-terminal 10*HisEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 130kDa (single chain), 100kDa ( alpha subunit) and 45kDa ( beta subunit) |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Girnita L, Worrall C, Takahashi SI, Seregard S, Girnita A. Something old, something new and something borrowed: Emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation. Cell Mol Life Sci. 2014;71:2403-27. |
Background
The insulin-like growth factor 1 receptor (IGF1R) is a ubiquitously expressed membrane -bound tyrosine kinase receptor that recognizes its two major ligands IGF1 and IGF2, and controls multiple essential cellular functions. IGF1R is highly overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney. IGF1R precursor Cleavage generates alpha and beta subunits. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. IGF1R promotes metastatic tumor initiation and progression in lung TME. IGF1R signaling has been profusely implicated as a critical contributor to cancer cell proliferation, survival, migration, and resistance to anticancer therapies, thus targeting IGF signaling is an attractive therapeutic strategy.
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