1μg (R: reducing conditions, N: non-reducing conditions).
Biotinylated CEACAM-8/CD66b His&Avi Tag Protein, Human
Biotinylated CEACAM-8/CD66b His&Avi Tag Protein, Human
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$470 USD
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Product Details
Product Details
Product Specification
| Species | Human |
| Synonyms | Non-specific cross-reacting antigen NCA-95，CGM6，Carcinoembryonic Antigen Gene Family Member 6，CD66b Antigen，NCA-95，CD67，Carcinoembryonic antigen CGM6，CD66b，CEACAM8，Carcinoembryonic Antigen Related Cell Adhesion Molecule 8，Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8，CD67 Antigen，CEA Cell Adhesion Molecule 8 |
| Accession | P31997 |
| Amino Acid Sequence | Gln 35-Ser 319, with C-terminal His&Avi tagQLTIEAVPSNAAEGKEVLLLVHNLPQDPRGYNWYKGETVDANRRIIGYVISNQQITPGPAYSNRETIYPNASLLMRNVTRNDTGSYTLQVIKLNLMSEEVTGQFSVHPETPKPSISSNNSNPVEDKDAVAFTCEPETQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLLSVTRNDVGPYECEIQNPASANFSDPVTLNVLYGPDAPTISPSDTYYHAGVNLNLSCHAASNPPSQYSWSVNGTFQQYTQKLFIPNITTKNSGSYACHTTNSATGRNRTTVRMITVSGGGSGGGSHHHHHHHHHHGLNDIFEAQKIEWHE |
| Expression System | HEK293 |
| Molecular Weight | 55-72kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Biotin |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Yoon, J. et al. (2007) J. Immunol. 179:8454.2. Feuk-Lagerstedt, E. et al. (1999) J. Immunol. 163:5592. |
Background
Carcinoembryonic antigen-related cell adhesion molecule 8 (CEACAM-8), also known as CGM6 and CD66b, is an approximately 95 kDa member of the human carcinoembryonic antigen (CEA) family that plays a role in cell adhesion, cell migration and pathogen binding. Human CEACAM-8 is composed of a 34 amino acid (aa) signal peptide, a 29 aa propeptide segment which is removed in the mature form, and a 286 aa CEACAM-8 region containing one V-type and two C2-type Ig-like domains. CEACAM family members are widely expressed in epithelial, endothelial, and hematopoietic cells, including neutrophils, T-cells, and NK cells. CEACAMs appear to be capable of transmitting signals that result in a variety of effects depending on the tissue, including tumor suppression, tumor promotion, angiogenesis, neutrophil activation, lymphocyte activation, regulation of the cell cycle, and regulation of adhesion. CEACAMs have now been associated with numerous intracellular signaling processes including cell adhesion, cell growth, recognition and differentiation, angiogenesis, and apoptosis.
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SDS-PAGE
ELISA
Immobilized Biotinylated CEACAM-8/CD66b His&Avi Tag Protein, Human (Cat. No. UA010698) at 2 μg/mL on Streptavidin precoated (0.5μg/well) plate, can bind CEACAM-6/CD66c Fc Chimera Protein, Human (Cat. No. UA010274) with EC50 of 0.14-0.22μg/ml.
