Recent Articles
How Atypical PKCζ Regulates Path...
Roles of Serine/Threonine Phosph...
Histone Crotonylation: Reshaping...
Pan Modification Microspheres for PTM Proteomics
1. Concept Posttranslational modifications (PTMs) diversify proteome functions and regulate nearly all cellular processes. Individual proteins may carry multiple PTMs with crosstalk between them. However, low abundance and high diversity...
Pan Modification Microspheres for PTM Proteomics
1. Concept Posttranslational modifications (PTMs) diversify proteome functions and regulate nearly all cellular processes. Individual proteins may carry multiple PTMs with crosstalk between them. However, low abundance and high diversity...
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Crotonylation Reshapes Histone Modification and Transcription
1. Concept Lysine crotonylation is a conserved histone acylation modification identified in 2011. It carries an unsaturated crotonyl group, structurally distinct from acetylation, and strongly promotes gene transcription. 2. Research...
Crotonylation Reshapes Histone Modification and Transcription
1. Concept Lysine crotonylation is a conserved histone acylation modification identified in 2011. It carries an unsaturated crotonyl group, structurally distinct from acetylation, and strongly promotes gene transcription. 2. Research...
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Lactylation Drives Tumor Immune Evasion
1. Literature Information This research elucidates a lactate–lactylation–METTL3–m6A–STAT3 signaling axis that remodels tumorinfiltrating myeloid cells and promotes immunosuppression, revealing a key mechanism of tumor immune escape. 2. Research Background Tumor...
Lactylation Drives Tumor Immune Evasion
1. Literature Information This research elucidates a lactate–lactylation–METTL3–m6A–STAT3 signaling axis that remodels tumorinfiltrating myeloid cells and promotes immunosuppression, revealing a key mechanism of tumor immune escape. 2. Research Background Tumor...
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Glycyllysine Modification Maintains Nuclear–ER Homeostasis
1. Literature Information This study reveals that glycyllysine modification is a versatile posttranslational modification regulating DNA damage response, telomere stability, endoplasmic reticulum (ER) ribosome quality control, ERassociated degradation and ERphagy....
Glycyllysine Modification Maintains Nuclear–ER Homeostasis
1. Literature Information This study reveals that glycyllysine modification is a versatile posttranslational modification regulating DNA damage response, telomere stability, endoplasmic reticulum (ER) ribosome quality control, ERassociated degradation and ERphagy....
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DNA Methylation: The Core of Epigenetic Research
1. Concept DNA methylation is a stable epigenetic modification that adds methyl groups to the 5carbon of cytosine (forming 5mC), mostly at CpG sites, without altering DNA sequence. It stably...
DNA Methylation: The Core of Epigenetic Research
1. Concept DNA methylation is a stable epigenetic modification that adds methyl groups to the 5carbon of cytosine (forming 5mC), mostly at CpG sites, without altering DNA sequence. It stably...
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Fumaroylation: A New Hub Linking Metabolism and Epigenetics
1. Concept Protein lysine fumaroylation is a novel posttranslational acylation modification where fumaroyl groups from TCA cycle intermediate fumarate are covalently attached to lysine residues. It acts as a molecular...
Fumaroylation: A New Hub Linking Metabolism and Epigenetics
1. Concept Protein lysine fumaroylation is a novel posttranslational acylation modification where fumaroyl groups from TCA cycle intermediate fumarate are covalently attached to lysine residues. It acts as a molecular...
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