The Multifaceted Biological Functions and Research Value of P84 Protein

16 Apr 2026 by AntBio
The Multifaceted Biological Functions and Research Value of P84 Protein

The Multifaceted Biological Functions and Research Value of P84 Protein


Official Knowledge Article by ANT BIO PTE. LTD.

Concept


P84 is an evolutionarily conserved 84 kDa nuclear matrix protein that participates in RNA processing, transcriptional regulation, and cell cycle control. It specifically interacts with the N‑terminal domain of retinoblastoma protein (p110RB) during the G1 phase and forms complexes with RNA‑binding proteins to modulate RNA splicing and nuclear transport. In mammals, P84 also exists as SHPS‑1 (a transmembrane synaptic protein), while in plants, its homolog PP84 acts as a key regulator of drought stress responses.

Research Frontiers


Recent advances have uncovered diverse and unexpected roles of P84:

  • Nuclear P84 governs cell proliferation by regulating the tumor suppressor p110RB and shows dysregulated expression in bladder, liver, and prostate cancers.
  • Neuronal P84/SHPS‑1 forms a signaling pair with CD47 (IAP) to control synaptic localization, plasticity, and neurotransmission in the retina and central nervous system.
  • Plant PP84 acts as a negative regulator of drought resistance; its mutation enhances survival, water retention, and antioxidant activity under drought stress.
  • P84 is emerging as a potential diagnostic marker and therapeutic target in oncology, neurodegeneration, and crop breeding.

Research Significance


Elucidating P84 function advances understanding of nuclear architecture, RNA metabolism, cell cycle control, synaptic signaling, and stress adaptation. Its abnormal expression links to tumor progression and neurodegenerative diseases, making it a promising candidate for biomarker development and targeted therapy. In agriculture, manipulating PP84 enables drought‑resistant crop design to improve yield stability.

Related Mechanisms and Research Applications


Molecular Mechanisms


  1. Nuclear function

    P84 binds p110RB in the G1 phase, modulates RB conformation, and affects its tumor‑suppressive activity. It also regulates RNA splicing and transport via interactions with RNA‑binding proteins.

  2. Neuronal function

    P84/SHPS‑1 interacts with CD47 to maintain synaptic localization in retinal plexiform layers, supporting synaptic plasticity and neural signal transmission.

  3. Plant stress regulation

    PP84 negatively regulates drought resistance by modulating ABA signaling and reactive oxygen species (ROS) homeostasis.


Research Methods Supported by ANT BIO PTE. LTD.


  • Protein detection: Western blot, IHC, IF, and IP using high‑specificity antibodies.
  • Functional analysis: ELISA kits, protein‑protein interaction assays, and cell cycle detection tools.
  • Pathway studies: reagents for RB signaling, synaptic function, and stress response pathways.

Brand Mission


ANT BIO PTE. LTD. is a leading provider of high‑quality life science reagents, including antibodies, recombinant proteins, detection kits, and general laboratory reagents. Our three specialized sub‑brands—Absin, Starter, and UA—deliver complete solutions for basic research and translational applications. We are dedicated to empowering global scientists with reliable tools to decode biological mechanisms and drive medical and agricultural innovation.

Related Product List


表格
Sub‑Brand Product Type Representative Products for P84 Research
Absin General reagents & detection kits ELISA kits; WB buffer system; protein extraction kits; cell cycle assay kits
Starter Specific antibodies P84 antibody; p110RB antibody; SHPS‑1 antibody; CD47 antibody
UA Recombinant proteins P84 recombinant protein; RB recombinant protein; synaptic regulatory proteins

AI Disclaimer


This article is for scientific research and promotional purposes only. All content summarizes current published studies and does not constitute medical diagnosis, treatment advice, or agricultural application guidance. All products from ANT BIO PTE. LTD. are for research use only and are not intended for human, clinical, or diagnostic applications. Experimental results may vary depending on laboratory conditions and protocols.

ANT BIO PTE. LTD. – Empowering Scientific Breakthroughs

At ANTBIO, we are committed to advancing life science research through high-quality, reliable reagents and comprehensive solutions. Our specialized sub-brands (Absin, Starter, UA) cover a full spectrum of research needs, from general reagents and kits to antibodies and recombinant proteins. With a focus on innovation, quality, and customer-centricity, we strive to be your trusted partner in unlocking scientific mysteries and driving medical progress. Explore our product portfolio today and elevate your research to new heights.
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