S100β as a Dual-Functional Biomarker in Neural Homeostasis and Neuroinflammation
ANT BIO Official Academic Article: S100β as a Dual-Functional Biomarker in Neural Homeostasis and Neuroinflammation
Exclusive Literature Interpretation by ANT BIO PTE. LTD.
Literature Information
This article interprets peer-reviewed publications regarding the molecular function, dual signaling roles, and disease-associated mechanisms of S100β, a key calcium-binding protein involved in astrocyte activation, neuroinflammation, and neurodegenerative disease progression.
Research Background
S100β acts as a pivotal dual-functional molecule: at physiological concentrations, it supports neuroprotection and synaptic plasticity; at elevated levels, it drives inflammatory cascades and neurotoxicity. This concentration-dependent switch makes it a core biomarker for traumatic brain injury, Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis.
Research Approach
The reviewed studies integrate molecular structural analysis, cell-based functional assays, animal disease models, and clinical sample detection to dissect S100β’s signaling networks, concentration-dependent roles, and pathogenic contributions in neural injury and neuroinflammation.
Research Outcomes
- S100β is a calcium-sensitive dimer that functions as both a neurotrophic factor and a DAMP (damage-associated molecular pattern).
- Its extracellular signaling is mediated mainly by the RAGE receptor, activating NF-κB, ERK1/2, and JNK pathways to drive microglial activation.
- Concentration determines functional polarity: nanomolar levels promote neuron survival; micromolar levels induce inflammatory storms.
- S100β is significantly elevated in multiple neurodegenerative diseases and serves as a specific biomarker for disease monitoring.
Product Empowerment by ANT BIO PTE. LTD.
To support accurate and reproducible research on S100β, ANT BIO PTE. LTD. provides a full set of validated reagents:
- Absin: General buffers, dilution reagents, IHC/IF detection kits, and ELISA supporting kits for stable experimental conditions.
- Starter: Highly specific anti-S100β monoclonal and polyclonal antibodies for Western blot, IHC-P, IF, and flow cytometry.
- UA: Recombinant S100β standard protein, positive control protein, and pathway-related functional proteins for quantitative calibration.
These reagents ensure specific recognition, low background, and high stability in S100β detection and functional analysis.
Brand Mission
ANT BIO PTE. LTD. is a professional supplier of life science reagents dedicated to providing high-quality antibodies, recombinant proteins, kits, and universal reagents for scientific research. Our three sub-brands (Absin, Starter, UA) cover a complete range of research needs to empower breakthrough discoveries in life science.
Related Product List
|
Catalog No. |
Product Name |
Applications |
Supported Brand |
|
S0B2117 |
S100β Recombinant Rabbit mAb |
IHC-P, WB, IF |
Starter |
|
S0B2117P |
S100β Recombinant Rabbit mAb, PBS Only |
IHC-P, WB, IF |
Starter |
|
S0B2247 |
S-RMab® S100β Recombinant Rabbit mAb |
IHC-P, WB, IP |
Starter |
|
S0B2247P |
S-RMab® S100β Recombinant Rabbit mAb, PBS Only |
IHC-P, WB, IP |
Starter |
|
S0B2055 |
S100A1 Recombinant Rabbit mAb |
IHC-P, ICC, FC |
Starter |
|
S0B0028 |
S100A13 Recombinant Rabbit mAb |
IHC-P, WB |
Starter |
Brand Promotion
ANT BIO PTE. LTD. – Empowering Scientific Breakthroughs
At ANTBIO, we are committed to advancing life science research through high-quality, reliable reagents and comprehensive solutions. Our specialized sub-brands (Absin, Starter, UA) cover a full spectrum of research needs, from general reagents and kits to antibodies and recombinant proteins. With a focus on innovation, quality, and customer-centricity, we strive to be your trusted partner in unlocking scientific mysteries and driving medical progress. Explore our product portfolio today and elevate your research to new heights.
