PTEN Companion Diagnostic Antibodies Direct Precision Cancer Therapy

1. Literature Information

This review establishes PTEN as a key tumor suppressor and demonstrates that PTEN IHC is a reliable companion diagnostic to predict PI3K/AKT/mTOR inhibitor response and immunotherapy efficacy.

2. Research Background

PTEN is one of the most frequently inactivated tumor suppressors. Its loss hyperactivates PI3K/AKT signaling, drives metabolic reprogramming, induces genomic instability, and causes immunotherapy resistance.

3. Research Approach

PTEN antibodies detect protein expression and subcellular localization via IHC. Loss of expression or nuclear exclusion indicates functional inactivation.

4. Research Outcomes

· PTEN loss predicts sensitivity to PI3K, AKT, and mTOR inhibitors.

· Nuclear PTEN maintains genome stability and DNA repair.

· PTENdeficient tumors are often resistant to antiPD1/PDL1 therapy.

· PTEN status reshapes the tumor immune microenvironment.

5. Product Empowerment

ANT BIO PTE. LTD. provides PTEN Recombinant Rabbit mAb (S0B2106).

· High specificity for PTEN with no crossreactivity to homologous proteins.

· Reliably detects cytoplasmic and nuclear PTEN in FFPE tissues.

· Recombinant production ensures outstanding batch consistency.

· Ideal for companion diagnostics and prognosis evaluation.

6. Brand Mission

ANT BIO PTE. LTD. is a professional life science reagent company offering highperformance antibodies, recombinant proteins, and kits. Our three subbrands empower global cancer research and precision medicine.

7. Related Product List

ANT BIO PTE. LTD. – Empowering Scientific Breakthroughs

At ANTBIO, we are committed to advancing life science research through high-quality, reliable reagents and comprehensive solutions. Our specialized sub-brands (Absin, Starter, UA) cover a full spectrum of research needs, from general reagents and kits to antibodies and recombinant proteins. With a focus on innovation, quality, and customer-centricity, we strive to be your trusted partner in unlocking scientific mysteries and driving medical progress. Explore our product portfolio today and elevate your research to new heights.