Lactylation: A Key Driver of Tumor Immune Evasion

Concept

Lactylation is a histone and nonhistone lysine acylation modification where lactate-derived lactyl groups are covalently attached to proteins. Discovered in 2019, it links glycolytic metabolism to epigenetic regulation. In the tumor microenvironment, high lactate levels drive lactylation, reshaping myeloid cell function and promoting immunosuppression and tumor immune evasion.

Research Frontier

Metabolism–epigenetics crosstalk is central to cancer progression. Lactate, long viewed as a waste product, is now known as a signaling molecule. Lactylation research focuses on:

· Lactate-driven epigenetic reprogramming in immune cells

· Mechanisms linking lactylation to m6A RNA modification

· Immunosuppressive pathways in the tumor microenvironment

· Targeting lactylation for cancer immunotherapy

Research Significance

Lactylation rewires the tumor immune landscape:

· Translates glycolytic lactate into epigenetic signals

· Activates immunosuppressive gene programs in myeloid cells

· Enhances m6A-mediated immune signaling

· Identifies novel targets to reverse immune evasion

Mechanisms and Product Applications

1. Lactate Accumulation in Tumor Microenvironment

Cancer cells rely on glycolysis, secreting large amounts of lactate. This creates a highlactate microenvironment that infiltrating myeloid cells take up, triggering histone lactylation.

2. Lactylation Upregulates METTL3

Lactylation enriches at the METTL3 promoter, opening chromatin and driving transcription. Elevated METTL3 enhances m6A RNA methylation.

3. m6ADriven Immunosuppressive Signaling

METTL3mediated m6A on Jak1 mRNA is recognized by YTHDF1, boosting JAK1 translation. Activated JAK1 drives STAT3 phosphorylation, inducing immunosuppressive genes (IL6, IL10).

4. Dual Regulation of METTL3

· Transcriptional: Lactylation increases METTL3 expression

· Posttranslational: Direct METTL3 lactylation enhances enzymatic activity

Brand Mission

ANT BIO PTE. LTD. advances immunometabolism research via its Starter sub-brand. Our LLactyl Lysine Rabbit Polyclonal Antibody (S0B0719) enables specific detection of lactylated proteins, supporting tumor immune evasion and therapeutic target studies.

Related Product List

ANT BIO PTE. LTD. – Empowering Scientific Breakthroughs

At ANTBIO, we are committed to advancing life science research through high-quality, reliable reagents and comprehensive solutions. Our specialized sub-brands (Absin, Starter, UA) cover a full spectrum of research needs, from general reagents and kits to antibodies and recombinant proteins. With a focus on innovation, quality, and customer-centricity, we strive to be your trusted partner in unlocking scientific mysteries and driving medical progress. Explore our product portfolio today and elevate your research to new heights.