InVivoMAb anti-mouse IL-4 Application
14 May 2025
I. Product Background
IL-4 is mainly expressed by activated Th2 cells and natural killer cells, and to a lesser extent by mast cells and basophils. It signals through the IL-4Rα. When bound to its receptor, IL-4 stimulates the proliferation of activated B and T lymphocytes and the differentiation of B cells into plasma cells. It also induces class switching to IgE in B cells, upregulates MHC class II production, and reduces the generation of Th1 cells, macrophages, IFNγ, and dendritic cell IL-12. Like other Th2-related cytokines, IL-4 is involved in the airway inflammation observed in the lungs of allergic asthma patients. The 11B11 monoclonal antibody has been shown to neutralize the biological activity of native or recombinant IL-4.
II. Application & Product Information
| Product No. | S0B0715 |
|---|---|
| Product Name | In vivo anti-mouse IL-4 Recombinant mAb |
| Host | Rat |
| Antigen Name | IL-4 |
| Synonyms | Interleukin-4, B-cell IgG differentiation factor, B-cell growth factor 1, B-cell stimulatory factor 1 (BSF-1), IGG1 induction factor, Lymphocyte stimulatory factor 1 |
| Clone No. | 11B11 |
| Antibody Type | Recombinant mAb |
| Antibody Isotype | Rat IgG1, k |
| Applications | In vivo IL-4 receptor stimulation (as a complex with IL-4), in vivo IL-4 neutralization, in vitro IL-4 neutralization, WB |
| Concentration | 4 mg/ml |
| Endotoxin | <1EU/mg |
